{"kind":"task","effective_mode":"full","benchmark":{"kind":"benchmark","effective_mode":"full","slug":"frontierscience","formal_name":"FrontierScience","introduction":"専門的な科学課題を解く能力を評価するベンチマークです。公開データはolympiadとresearchに分かれ、競技問題と研究課題を区別して扱います。\n\nFrontierScience evaluates the ability to solve expert-level scientific tasks. Its public data separates olympiad and research problems so that competition and research tasks can be examined independently.","introduction_ja":"","introduction_en":"","category":"Category not supplied","task_count":null,"acquisition_status":"Acquisition status not supplied","official_url":"https://huggingface.co/datasets/openai/frontierscience","indexing_mode":"noindex"},"task_id":"bd32a9c5-d7d6-55ad-82ac-88896d5e3dff","task_key":"olympiad--test--90ddb7c3~2d4bf1~2d43b6~2d820a~2dc89f3858781a","task_revision_id":"1","upstream_id":"90ddb7c3-4bf1-43b6-820a-c89f3858781a","short_description":"Two circos plots displayed that an *in vitro* cell line in which the expression…","config":"olympiad","split":"test","body":"{\"problem\":\"Two circos plots displayed that an *in vitro* cell line in which the expression of gene \\\"C\\\" has been knocked down using siRNA demonstrated detailed pathways that were upregulated or downregulated in these cells compared to the wild-type cells obtained via RNAseq. The upregulated pathways include the PD-1/PD-L1 axis (p-value < 0.001), cell cycle (p-value < 0.001), DNA damage repair (p-value < 0.001), mTOR signalling (p-value = 0.002), lipid biogenesis (p-value = 0.007), autophagy (p-value = 0.011), Parkinson's disease (p-value = 0.026), Atherosclerosis (p-value = 0.037), DNA splicing (p-value = 0.043), and TCA cycle (p-value = 0.049). On the other hand, the downregulated pathways include GPCR signalling (p-value &lt;0.001), EGFR signalling (p-value &lt;0.001), N-glycan biosynthesis (p-value < 0.001), Growth hormone receptor signalling (p-value < 0.001), Salmonella infection (p-value = 0.009), Shigella infection (p-value = 0.011), Estrogen signalling (p-value = 0.014), Epstein-Barr virus infection (p-value = 0.023), Insulin resistance pathway (p-value = 0.037), and Glycolysis/ gluconeogenesis (p-value = 0.042). When the protein levels of these genes were assessed through mass spectrometry, similar results were observed, except for the PD-1/PD-L1 proteins, which were decreased instead. Which of the identified pathways can explain this discrepancy?\\n\\nThink step by step and solve the problem below. At the end of your response, write your final answer on a new line starting with “FINAL ANSWER”. It should be an answer to the question such as providing a number, mathematical expression, formula, or entity name, without any extra commentary or providing multiple answer attempts.\",\"subject\":\"biology\"}","display_format":"text","language":"","answer_status":"published","assets":[],"source_url":"https://huggingface.co/datasets/openai/frontierscience","history":"initial import","indexing_mode":"noindex","subproblems":[],"grids":[]}