FrontierScience / 90ddb7c3-4bf1-43b6-820a-c89f3858781a / Two circos plots displayed that an *in vitro* cell line in which the expression…

Problem

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Two circos plots displayed that an *in vitro* cell line in which the expression of gene "C" has been knocked down using siRNA demonstrated detailed pathways that were upregulated or downregulated in these cells compared to the wild-type cells obtained via RNAseq. The upregulated pathways include the PD-1/PD-L1 axis (p-value < 0.001), cell cycle (p-value < 0.001), DNA damage repair (p-value < 0.001), mTOR signalling (p-value = 0.002), lipid biogenesis (p-value = 0.007), autophagy (p-value = 0.011), Parkinson's disease (p-value = 0.026), Atherosclerosis (p-value = 0.037), DNA splicing (p-value = 0.043), and TCA cycle (p-value = 0.049). On the other hand, the downregulated pathways include GPCR signalling (p-value &lt;0.001), EGFR signalling (p-value &lt;0.001), N-glycan biosynthesis (p-value < 0.001), Growth hormone receptor signalling (p-value < 0.001), Salmonella infection (p-value = 0.009), Shigella infection (p-value = 0.011), Estrogen signalling (p-value = 0.014), Epstein-Barr virus infection (p-value = 0.023), Insulin resistance pathway (p-value = 0.037), and Glycolysis/ gluconeogenesis (p-value = 0.042). When the protein levels of these genes were assessed through mass spectrometry, similar results were observed, except for the PD-1/PD-L1 proteins, which were decreased instead. Which of the identified pathways can explain this discrepancy?

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biology

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Source and history

upstream_id / Original problem ID

90ddb7c3-4bf1-43b6-820a-c89f3858781a

task_id

bd32a9c5-d7d6-55ad-82ac-88896d5e3dff

task_key

olympiad--test--90ddb7c3~2d4bf1~2d43b6~2d820a~2dc89f3858781a

task_revision_id

1

config / split

olympiad / test

Official source

initial import