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FrontierScience / f7b49518-6e84-44e3-9480-4cf91d149702 / In devising a drug delivery system for an in vitro experiment using cultured…

Problem

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problem

In devising a drug delivery system for an in vitro experiment using cultured hepatic cells, a PhD student designed three different approaches:

- Covalently linking the payload (hereby a small non-bioactive hydrophobic molecule) to a DNA origami structure
- Conjugating the payload to a nanobody designed to target a currently unidentified surface orphan receptor.
- Linking the payload to a DNA tetrahedron with 20nt-long sides

Due to the difficulty of synthesizing DNA nanostructures, the researcher decided to focus on the nanobody approach. After trying to identify the target of the orphan receptors to figure out if it is involved in a phagocytosis-like process, the student's PI told them that the identification does not matter and it would work even if this receptor does not canonically induce endocytosis. What cellular process is the PI depending upon for this novel approach to work?

Think step by step and solve the problem below. At the end of your response, write your final answer on a new line starting with “FINAL ANSWER”. It should be an answer to the question such as providing a number, mathematical expression, formula, or entity name, without any extra commentary or providing multiple answer attempts.

subject

biology

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Source and history

upstream_id / Original problem ID: f7b49518-6e84-44e3-9480-4cf91d149702
task_id: a0723d07-6f72-5c50-9467-ee725a800e53
task_key: olympiad--test--f7b49518~2d6e84~2d44e3~2d9480~2d4cf91d149702
task_revision_id: 1
config / split: olympiad / test

Official source

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