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MMLU-Pro / 6111 / A phase 2, multicenter trial was conducted to determine the efficacy of a new…

Problem

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question

A phase 2, multicenter trial was conducted to determine the efficacy of a new vaccine for prevention of HIV infection. The study enrolled 4000 subjects, aged 20 to 65 years. Of these subjects, 2100 were men and 1900 were women; 2500 were white, 1000 were African American, 300 were Hispanic, and 200 were Asian/Pacific Islanders. Results of the trial showed no overall benefit of the vaccine. However, post hoc analysis disclosed a small but statistically significant vaccine protection among African American subjects. Which of the following is the most accurate rationale for questioning the validity of efficacy analysis of the HIV vaccine among the African American study subjects?

category

health

options

  1. HIV infection is more prevalent among African American populations
  2. The vaccine had no overall benefit
  3. The study was not blinded
  4. The age of the subjects could have affected the results
  5. The study did not disclose the number of subjects who were actually infected with HIV
  6. There was a Type II error
  7. Vaccine response among African American subjects was not the primary outcome measure
  8. The vaccine response varied across different ethnicities
  9. There was a Type I error

src

ori_mmlu-professional_medicine

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Source and history

upstream_id / Original problem ID
6111
task_id
d4d847c2-7e0f-5632-bc1c-048818bebe7b
task_key
default--test--6111
task_revision_id
1
config / split
default / test

Official source

initial import