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MMLU / A 62-year-old woman comes to the physician because of low back pain for 1 week.…

Problem

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question

A 62-year-old woman comes to the physician because of low back pain for 1 week. Menopause occurred 10 years ago. Physical examination shows localized tenderness over the lumbar spine after movement. X-rays of the spine show a compression fracture of L1-2. A DEXA scan shows decreased bone mineral density. Serum calcium and phosphorus concentrations and serum alkaline phosphatase activity are within the reference ranges. A bisphosphonate drug is prescribed. The expected beneficial effect of this drug is most likely due to which of the following actions?

choices

  1. Decreased insulin-like growth factor-1 concentration
  2. Decreased osteoclast activity
  3. Decreased osteoprotegerin production
  4. Increased 1,25-dihydroxycholecalciferol concentration

subject

professional_medicine

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